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Antioxidants 12 , 974 (2023)

doi: 10.1016/j.jalz.2016.02.010 42 OttAStolkRPvan HarskampFPolsHAHofmanABretelerMM

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It is: Not FDA-approved Sold as a research chemical Often mislabeled or impure Completely unregulated Known risks include: Severe hypoglycemia (low blood sugar)

This mechanism of eNOS uncoupling is unique in that it occurs in the reductase domain, unlike other uncoupling mechanisms that occur in the oxygenase domain, and can be inhibited by L-NAME ( In vivo studies have confirmed the association of eNOS S-glutathionylation with endothelial dysfunction in hypertension, aging, and cardiovascular diseases (Suvorava et al., 2015)