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They are generally well tolerated

For biosynthesis, it seems the only strategy to prolong the half-life is a ligand fused with a terminal albumin or Fc domain, whose critical points are length and location

2 Establishing the correct diagnosis of malignant peripheral nerve sheath tumor remains a challenge not only due to morphological and immunohistochemical complexity (particularly outside the NF1 context) but also because a number of other sarcomas, benign soft tissue tumors, and non-epithelial tumors (especially melanoma) can appear similar to malignant peripheral nerve sheath tumors

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