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This means adopting and sticking to significant lifestyle changes

10.1016/j.bbih.2020.100197 23 DemirE

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Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied

Among patients prescribed any of the top four drugs (Ozempic, Mounjaro, Wegovy, Rybelsus) between 2021 and 2022, 65% were non-Hispanic White and 14% were Hispanic or Latino