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Previous research indicates no significant differences in fasting acylated ghrelin, total PYY, active GLP-1, and CCK between rapid and gradual weight loss when the amount of weight loss is controlled for [70]

Common concerns are: Nausea Diarrhea Vomiting Constipation Stomach pain Decreased appetite Headache More serious side effects such as pancreatitis or gallbladder issues are rare but possible

The natriuretic action of GLP-1 is mainly mediated by inhibition of NHE3 activity through a PKA-dependent mechanism (71, 8991) ( Figure 2 )

That might sound alarming, but its actually not that surprising

The findings come from cell cultures and animal models, not completed human clinical trials