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Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1

Richardson and Stojiljkovic, 2001

The brain tissue of PD patients is typically characterized by the death of dopaminergic, neuromelanin-containing neurons in the area of locus coeruleus and substantia nigra

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However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]