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First-time users begin with a low 2.5 mg subcutaneous dose administered once weekly, primarily to establish tolerability

This study did not conduct a subgroup analysis to assess the impact of co-administered medications and a sensitivity analysis to assess unmeasured confounding or hidden bias (if any) on the risk of hypoglycemia

As with many medical weight management treatments, GLP-1based therapies may cause side effects, particularly as the body adjusts during the early stages of treatment

The evidence for direct, primary effects on thyroid, estrogen, progesterone, or testosterone is weak

PlexusDx compounded semaglutide works for both indications and is $189 monthly month-to-month, or from $149/mo on the 6-month plan without requiring insurance approval or documentation of diabetes status