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doi: 10.3389/fimmu.2018.01605 422 JohnstonSCStainesDRMarshall-GradisnikSM

Splenectomy significantly increased Hb levels with a marked reduction in reticulocyte count when compared with control 4.2 / mice (Figure 6B)

This is a retrospective, single-center study, but real-life cohort data encompass a broader range of patients compared to randomized controlled studies, which often exclude individuals with various comorbidities

Zhang H, Wei J, Xue R, et al

Common reports include: Waking fewer times during the night Feeling more refreshed upon waking Improved daytime energy and mood Reduced stress reactivity Better recovery from exercise The stress-modulating effects often become noticeable during this window as cortisol patterns normalize