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Abbreviations AF: Annulus fibrosus ASC: Adipose-derived stem cell BMP-2: Bone morphogenetic protein-2 BMSC: Bone marrow-derived stem cell CD: Chondrodystrophic CLC: Chondrocyte-like cell CTGF: Connective tissue growth factor DH: Disc height ECM: Extracellular matrix EP: End plate GAG: Glycosaminoglycan GDF-5: Growth and differentiation factor-5 IGF-1: Isulin-like growth factor-1 IVD: Intervertebral disc MSC: Mesenchymal stromal (stem) cells MMP: Matrix metalloproteinase MRI: Magnetic resonance imaging NC: Notochordal cell NCCM: Notochordal cell conditioned medium NCD: Non-chondrodystrophic NP: Nucleus pulposus NPPC: Nucleus pulposus progenitor cell

Cinelli, M

Cognitive behavioural therapy (CBT) can help modify eating behaviours, manage stress (which may influence UC activity), and address body image concerns

206 GLP-1 has also been shown to reduce blood glucose levels via direct inhibition of glucagon secretion from islet alpha-cells in an insulin-independent manner

It demonstrates superior efficacy in reducing body weight compared with previous GLP-1 therapies and offers a once-weekly dosing regimen, providing patients with greater convenience [10]