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MPMs were then lipoprotein starved further in culture for 18 hours in the absence versus presence of increasing concentrations of cholesterol, acetylated LDL or vehicle with (+) or without () 300 M TMAO dehydrate (Sigma)

Drug Discov Today 18, 807817, doi: 10.1016/j.drudis.2013.05.011 (2013)

Zonation differences are associated with phase I and phase II metabolism enzymes, with a predominant centrilobular localization of most constitutively expressed P450s (Figure 1A and 1B) and other phase I enzymes and a predominant periportal expression of most phase II enzymes

The extended activity attributed to IGF-1 LR3 comes from its reduced affinity for IGF binding proteins

Cipolletta, G