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Homocysteine serves as a precursor to hydrogen sulfide (H 2 S), a gasotransmitter generated through the transsulfuration process catalyzed by the enzymes cystathionine -synthase and cystathionine -lyase
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By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications
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