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The FDA's 2023 briefing to the Pharmacy Compounding Advisory Committee cited the lack of sufficient clinical evidence for therapeutic compounding approval

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But you can leave it out of the fridge for up to 28 days as long as its stored at a temperature of 86F (30C) or less and doesnt freeze or come into contact with light

The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly