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DOI Lincoff AM, Brown-Frandsen K, Colhoun HM, et al

Br J Clin Pharmacol 49:291301 Dart RC, Kuffner EK, Rumack BH (2000) Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review

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The copper complex has stability characteristics that depend on the formulation environment, and a formulation outside the appropriate pH range can affect the integrity of the copper complex over the formulations shelf life