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Epub 2020 Feb 5..10.1111/jdv.16182 [PubMed: 31919924] [CrossRef] 71

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In animal and cellular models, metformin reduces cardiomyocyte hypertrophy and lactate dehydrogenase release by downregulating HIF-1 and PPAR-, implicating the HIF-1/PPAR- axis in limiting pathological growth (Liu et al., 2022)