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In an RCT of 44 youth assigned to lithium only or lithium + tamoxifen 2040 mg, the augmentation with tamoxifen group had significantly more 50% reduction proportion in the active treatment augmentation group for mania ratings compared to placebo augmentation (Fallah et al., 2016)

Mice tolerated the treatment well throughout the study period

At the age of 24 weeks, mice were anesthetized with isoflurane (Cp-pharma, Burgdorf, Germany) and blood was collected by cardiac puncture

If magnesium levels are low, the production of glutathione can slow down