To recapitulate liver development, the differentiation of PCSs comprises three main steps: PSCs to DE, DE to hepatic progenitor cells (HPCs), and HPCs to HLCs
Abbreviations AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase BBB: Blood-brain barrier CNS: Central nerve system EAAT-1: Excitatory amino acid transporter 1 EAE: Experimental allergic encephalomyelitis H 2 O 2 : Hydrogen peroxide MCI: Mild cognitive impairment MS: Multiple sclerosis MSU: Monosodium urate mTOR: Mammalian target of rapamycin NO: Nitric oxide ONOO : Peroxynitrite PD: Parkinsons disease RNS: Reactive nitrogen species ROS: Reactive oxygen species SCI: Spinal cord injury SOD: Superoxide dismutase TFEB: Transcription factor EB TLR: Toll-like receptor UA: Uric acid VEGF: Vascular endothelial growth factor XO: Xanthine oxidase References Burtscher J, Millet GP, Place N, Kayser B, Zanou N
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Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
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