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et al., 2023) suggest that its pathogenesis is related to the mechanism of ROS

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By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production

Yamada T, Ikejiri K, Kotani M, Kusakabe T

Many people with histamine intolerance report uncomfortable skin rashes, redness of the face, swelling of extremities, and a wide variety of both neurological and gastrointestinal symptoms