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A 2025 letter in Diabetes Care argues that microdosing via multidose pens can help patients who struggle with gastrointestinal side effects by allowing smaller, incremental dose adjustments, though the authors emphasize this is a pragmatic, clinician-directed strategy

Patients learn injection technique during their first dose at the clinic and self-administer at home thereafter, typically into the abdomen, upper thigh, or back of the upper arm

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