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Even with a research history dating back to the 1970s, DSIP has somewhat fallen out of the scientific literature in the past 20-30 years, and much about its health applications is subject to debate

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10.1136/gut.2007.140806 Gut

The theoretical concern: Any compound that stimulates cell proliferation, angiogenesis, and gene expression modulation raises oncological questions

One study from Liu-Ambrose et al observed significant reductions in global brain volume following 1 year of high-intensity progressive RT (2 sets of 6-8 repetitions at 70%85% of 1RM, either once or twice weekly) in older women free from MCI (Liu-Ambrose et al., 2010)