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Real-world outcomes can differ because people often change their normal behaviour in a research environment, whereas real-world settings give us a stronger indication of how effective medications are in the more unpredictable environment of peoples day-to-day lives

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109 However, in 2022, the Biden Administration reversed this direction, reinstating the IPO list and removing hundreds of codes that had been added to the ASC CPL, citing safety concerns and the need for further procedural review