J Clin Investig 111(6):785
Among relatively healthy populations at baseline, prospective studies in people over 60 have produced mixed results, with some finding associations between elevated B12 and mortality (Mendonca, 2018
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They pointed out in their manuscript that although the joint modulation of surface chemistry and PS-80 density, is a useful tool to adjust BBB penetration, functional or behavior evaluations, for instance, cell death, neuroinflammation, or larger animal models, are lacking in the study