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Cluster 1 was associated with steroid hormone biosynthesis and retinol metabolism, cluster 2 with the pentose phosphate pathway (PPP) and glycolysis, cluster 3 with fatty acid synthesis and pyruvate metabolism, cluster 4 with lipid droplet metabolism and cluster 5 with cellular amino acid catabolic pathways (Fig

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In addition, there is a likely analogy (see for review i.e., (Seiwerth et al., 2018)) with the attenuated fibrosis and scar formation in other tissues (i.e., the skin, muscle, tendon, and ligament) (Mikus et al., 2001

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Busulfan is an anticancer drug that kills undeveloped germ cells, affects spermatozoal production, and induces male infertility, and the drug has been used to establish a model of oligospermia