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Timing Protocols : Some research suggests that administration timing relative to meals or exercise may influence both effectiveness and side effect profiles

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Journal of Nutritional and Environmental Medicine 2007 16:3-4, 212-226 doi=10.1080%2F13590840701791863 Catherine S

Front-loading protein ensures adequate intake before satiety makes eating difficult later

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)