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Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells

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[6] Regulatory bodies including the MHRA and EMA have included pancreatitis as a potential adverse effect in the prescribing information for GLP-1 agonists

It is thought that the loss of incretin effect is from (1) a reduction in secretion of incretin hormone in response to nutrients (hyposecretion) and/or (2) a reduction in insulinotropic effect on pancreatic beta cells (insulin resistance)

Plasma half-life is short (~10 min), but cellular GSH pools turn over more slowly (2472 hours)