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The data examined in this report show that most commercial patients face significant hurdles: large denial rates (often two-thirds of requests), multi-day delays (median ~6 days if not instant-approve), and high first-fill abandonment (fill rates commonly 60%)

Fasting serum insulin levels also decreased by up to 70.9% after 48 weeks, which may improve insulin resistance but may require additional monitoring in certain patients

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Counterweights without softening: Hims & Hers was referred to the DOJ in February 2026 for potential federal law violations

What are the main side effects of retatrutide seen in phase 2 studies