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The most commonly reported side effects in trials are nausea, vomiting, and decreased appetite consistent with other incretin-based therapies

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The percentage of weight loss due to fat in the combination cohort was 92.8%, compared with 71.8% for semaglutide alone Semaglutide combined with bimagrumab preserved lean body mass, with only a 2.9% muscle loss compared to 7.4% for semaglutide when used alone