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Numerous etiologic factors have been proposed, including physiologic factors, reactive factors, developmental factors, racial factors, Peutz-Jeghers syndrome, environmental stress, exposure to sunlight, trauma, smoking, medications such as antimalarial agents, hemochromatosis, systemic conditions such as Addisons disease and other endocrine disturbances, chronic pulmonary disease, and idiopathy

Available in natural flavors (Watermelon or Orange)

Kidney function tests, liver enzyme panels, and lipid profiles should be reviewed at baseline and periodically during therapy, since both drug classes can influence metabolic markers

Unlike retatrutide, tirzepatide only binds to 2 hormone receptors, GLP-1 and GIP, and is available with a prescription for weight management and type 2 diabetes

Serious but rare side effects include pancreatitis, gallbladder disease, gastroparesis (stomach paralysis), hypoglycemia, and kidney disease