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The authors reported that conversion of the N-terminal His to Phe resulted in an Ex-4 analog with improved efficacy at inducing insulin release while eliciting reduced levels of receptor internalization and -arrestin-2 recruitment 49

The procedure is generally well tolerated by most patients

If side effects persist beyond four to six weeks, it is worth discussing a dose adjustment with your doctor

Common Side Effects of Semaglutide Many people experience mild to moderate side effects when starting semaglutide

The rapid glucose load may also cause blood sugar fluctuations, particularly in patients taking concurrent diabetes medications like insulin or sulfonylureas, which could compound feelings of nausea or discomfort