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66 , 67 Restingstate functional MRI data acquired from nonspecific CLBP patients at baseline and after a manipulation for back pain intensification implicated a role of the mesocortical and mesolimbic pathways, potentially mediating the contribution of pain sensitization to pain chronification in CLBP

However, population level studies show that most individuals who recover develop only low levels of neutralizing antibodies 3 , indicating that neutralizing antibodies are likely to have a relatively limited impact on resolving disease

Li SQ, Zhu S, Han HM, Lu HJ, Meng HY