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When combined with 6 mg hyaluronic acid, the effects were significantly enhanced beyond either treatment alone
Figure 3: Kaplan-Meier Curves for Overall Survival in Non-squamous NSCLC in Study JMDB Maintenance Treatment Following First-line Non-Pemetrexed Containing Platinum-Based Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was evaluated in Study JMEN (NCT00102804), a multicenter, randomized (2:1), double-blind, placebo-controlled study conducted in 663 patients with Stage IIIb/IV NSCLC who did not progress after four cycles of platinum-based chemotherapy
Because of this, I recommend any patient who is symptomatic and has suboptimal levels of vitamin B12 (as defined above) consider a trial of sublingual B12
There may be instances where certain conditions, such as poor nutrition, intestinal issues, infections, and cancer, may lead to B12 deficiency
Yet, the benefits often outweigh these risks, preventing severe bleeding
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