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Phentermine/topiramate (Qsymia) Qsymia has phentermine and topiramate as its active ingredients

The aminobenzyl alcohol motif is the classical choice for this role Several derivatives have since been developed to fine-tune performance, including: Differently substituted aminobenzyl alcohols Extended benzyl alcohol variants Heteroaryl-linked spacers These structural modifications allow chemists to optimize: Payload release kinetics Aqueous solubility Overall linker stability Opportunities for ADC Development This structural diversity provides researchers with the flexibility to tailor -glucuronidase-cleavable linkers to specific therapeutic goals, while retaining the robust enzymatic trigger that ensures reliable release

The vegan R library (v2.5.6) (Oksanen et al., 2019) was used to compute alpha diversity [Shannon index (Shannon, 1948) and Chao1 estimator (Chao, 1984)] at ASV level

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