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The Metabolism Barrier When you drastically cut calories to hit a goal like 15 pounds in 30 days, your body can interpret it as a famine and enter starvation mode. This dramatically lowers your metabolism to conserve energy, making continued progress extremely difficulta phenomenon known as the plateau effect. 2

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The angiogenesis data also applies to cardiovascular health

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Bupropion also has a stimulating effect, which can be beneficial for patients with depression-related lethargy, but may exacerbate anxiety in some individuals