It is a big question
The genes affected by semaglutide included markers of inflammation and plaque stability that are associated with leukocyte recruitment [e.g., interleukin-1 (IL-1) receptor antagonist, IL-6, monocyte chemoattractant protein (CCL2), OPN], leukocyte adhesion [selectin E, vascular cell adhesion molecule-1 (VCAM1)], leukocyte extravasation and plaque stability (e.g., MMP3, MMP13, CCL2), and plaque rupture and hemorrhage (CD163)
Even when these patients followed instructions and consulted their doctor, they came down with serious and even life-threatening medical conditions
Across STEP 1, 3, 4, and 8, mean percentage weight reductions ranged from 14.9 to 17.4% from baseline to 68 weeks in individuals with obesity or overweight without T2D [10,11,12,13]
Researchers generally dont view these peptides as competitors