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There are several signaling pathways, such as the phosphoinositide 3-kinases (PI3K)/protein kinase-B (Akt) pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)/nuclear factor kappa B (NF-B) pathway, which demonstrates a decrease in the inflammatory reaction and mediators upon activation of 7nAChRs [35, 36]

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In addition to direct effects on ion channels, neurotransmitters may bind to G-protein coupled receptors, thereby eliciting cell-signaling effects that could result in metabolic changes (e.g., alterations in activity of various enzymes) within a postsynaptic cell (14)