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This model is failing two distinct groups of patients: The Acute Patient: Recent data indicates that the average wait time for a new patient appointment with a neurologist in the United States is approximately 34 days , with nearly 20% of patients waiting longer than 90 days [1]

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49 Furthermore, the constitutive expression of claudin-1 in gut epithelium in mice resulted in decreased claudin-7 expression and enhanced susceptibility to acute colitis