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Similarly, the expression of key autophagy genes, such as ATG5 , ATG7 , and BECN1 , is downregulated during normal aging in the human brain [209]

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In addition, differences in supplement formulation, dosage, sample size, and intervention durationtypically ranging from 36 monthsfurther amplify variability among studies (198, 199)

Early trials suggest these might produce even greater weight loss, potentially approaching 30% or more

*Correspondence: Neda Roshanravan, [email protected] Dehghan, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers