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One potential mechanism is thought to involve activation of the central nervous system, with the area postrema (AP) and nucleus of the solitary tract (NTS) and the intermediolateral nucleus (IML) of the spinal cord similarly activated by administration of GLP-1RA 29,30

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Lee CJ, Jang TY, Jeon SE et al (2024) The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression

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With better circulation comes a whole host of benefits including better oxygen uptake, nutrient delivery, and waste removal, which can both increase athletic endurance and speed up recovery following exercise