This review will briefly cover the history of GLP-1 discovery and development of incretin-based drugs
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At present, most of the research is based on animal models and in vitro experiments, and a few pharmacological effects have been clinically confirmed, especially the hypoglycemic effect of catalpol has been verified in the endocrine field, catalpol tablets have entered the phase 2 clinical study (CTR20220555) in China, aiming at evaluating the pharmacokinetics, efficacy and safety of catalpol tablets in patients with type 2 diabetes, small molecular monomer drugs have begun to face the clinic with suitable dosage forms
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ERTU was reported to be noninferior to placebo with respect to the composite outcome of cardiovascular death, nonfatal MI, or nonfatal stroke [101]