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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

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Studies in murine models [113,114] showed the effect of melatonin on antioxidant systems, producing a statistically significant reduction in NOS and iNOS activity [113], as well as an increase in Nrf2 and SIRT-1 levels [114]

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Strengthening the skin barrier and protecting it from external factors