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Our early experience suggests GLP-1 agonists are safe in MS patients, who have a similar tolerability to the general population on this medication class and measurable and sustained but somewhat less than anticipated weight loss

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No tolerance developed to this protective effect, which appeared to be mediated by (1) the activation of 5-HT 1A receptors, as it was antagonized by the administration of WAY100635 30 min before stress exposure

While not as potent as pharmaceutical DPP-4 inhibitors, these botanicals show modest but measurable effects on enzyme activity