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Within the hepatic environment, TMA is subjected to oxidation by flavin-containing monooxygenases (FMO), resulting in the conversion of TMA to TMAO, the fully oxidized derivative of the compound (Gatarek and Kaluzna-Czaplinska, 2021

Overall, this study suggests that Tesofensine has the potential to act as an antidepressant by enhancing gene expression and promoting the formation of new cells in the hippocampus

& Klingenspor, M