To replicate specific mitochondrial GSH mechanisms and data from in vivo mice models, a mitochondrial compartment needs to be added
Discussion In this study, we developed ERK5-CHAMPs, which can induce close proximity between HSP90 and the target protein ERK5, and mediate the UPS-dependent degradation of ERK5, impairing its kinase activity, nuclear translocation, and transactivation functions
Reconstitute closer to what the cycle needs
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