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Treatment discontinuation due to side effects occurred in 4.3%, 7.1%, 6.2%, and 2.6% of participants in the 5, 10, 15 mg, and placebo groups, respectively [18]

Temperatures above 30C (86F)such as in a warm car, sunny windowsill, or bathroom cabinet near a heat sourcecan degrade compounded semaglutide within 12 hours

But wait, there was a twist

However, because the drug also has weight-loss effects through mechanisms such as increased satiety, reduced appetite, and delayed gastric emptying, it is now also prescribed for the treatment of obesity

In February 2026, OptumRx removed the BMI threshold from its cardiovascular reauthorization criteria