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It is important to remember that the effects of semaglutide do not disappear overnight

[11] Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), [12] especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress

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Transient water retention or peripheral edema during initial dosing

Considering the recent X-ray crystallography and cryo-EM data, which revealed that GSH and Glu could bind to different domains of GLR3.4 for ion channel activation 30 , it would be intriguing to investigate whether GSH binds to GLR3.3 and further determine the potential relationship between GSH and Glu in activating GLR3.3