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PubMed Central, doi:10.1210/jc.2011-2216.

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By injecting mice transplanted with human islets with an antagonist against the human glucagon receptor, the blood glucose level in these animals was changed from human blood glucose to the blood glucose observed in nude mice, suggesting that the glucagon signal from human alpha cells is indeed responsible for determining the glucose set point [56]

If improvements in sleep quality and deep sleep markers (selfreported) show up and theres no adverse effect, they may continue at that dose for 24 weeks before considering any increase (e.g., to 250 mcg)