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The applicant further acknowledged the concerns CMS ( included in the CY 2026 OPPS/ASC proposed rule regarding the Axoguard HA+ Nerve Protector TM application and agreed that demonstrating improved clinical outcomes in patients is essential to meeting the substantial clinical improvement criterion

These variations imply potential modulatory actions on stress responses, possibly through interactions with opioidergic systems and broader endocrine signaling pathways

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