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These markers enable evaluation of hepatic and renal function, systemic inflammation, and long-term glycemic controls

In research settings, Semaglutide has been observed to activate GLP-1 receptors, leading to improved insulin sensitivity and delayed gastric emptying

At the time of the terminal experiments, hemodynamic measurement was performed by using a Mikro-Tip catheter (SPR-407, Millar Instruments, Houston, TX) to obtain left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic pressure (LVESP), heart rate, maximal slope of systolic pressure increment (+dP/dt) and diastolic pressure decrement (dP/dt)