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Thus, access to the brain parenchyma for peripherally administered GLP1 receptor agonists via the ventricular system seems unlikely, though probably deserves further detailed experimental attention in order to produce an unequivocal answer

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The SURMOUNT-OSA trials revealed that Tirzepatide dramatically reduced obstructive sleep apnea severity by finding that the drug decreased case patients' apnea-hypopnea index (AHI), a measure of breathing interruptions, by an estimated 2024 events per hour more than controls, depending on whether patients were using positive airway pressure (PAP) therapy at baseline