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Conversely, chronic periodontal inflammation amplifies systemic inflammatory cascades and immune dysregulation, aggravating insulin resistance and hyperglycemia, thereby promoting GDM and contributing to a bidirectional pathogenic cycle (43, 48)

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Closest Analog: Cagrilintide + Semaglutide REDEFINE 1 (Garvey et al., NEJM 2025) is the only Phase 3 trial of an amylin + incretin co-administered combination in adults without diabetes