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This corresponds to a natural circadian trough that exists independent of medication

Biochimie 82, 915926 (2000)

Functional brain imaging studies have reported a decrease in synaptic connectivity and neuronal circuitry in the PFC and hippocampus in depressed patients (Perlman et al., 2012

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Animals were allowed access to water ad libitum and fed on a standard dry diet (Formula 2050 containing 20% crude protein, 5.4% fat, 40.1% carbohydrate, 8.1% crude fiber, 18.4% neutral detergent fiber and 6.1% ash - Teklad Diets, Madison WI) supplemented with biscuits and fresh fruits