3.3 Potential biomarkers associated with PCa prognosis A total of 48 articles ( Table 4 , Supplementary Table 4 ) (50, 58, 59, 61, 63, 64, 70, 71, 73, 74, 80, 86, 88, 109, 110, 113, 124155) evaluating 147 potential biomarkers related to PCa prognosis were identified across 11 countries/territories
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To calculate free energy, we performed well-tempered single-walker metadynamic simulations up to 15 ps 31
In target tissues, the Type 1 IGF-1 receptor, which is homologous to the insulin receptor, is activated by IGF-1, leading to intracellular signaling which stimulates multiple processes resulting in statural growth
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